T淋巴细胞_____抗原，肿瘤;

肿瘤抗原MAGEA亚家族HLAA2限制性CTL表位的预测及分析

http://www.100md.com 《第四军医大学学报》 2004年第24期

T淋巴细胞,,抗原，肿瘤;,MAGEA亚家族;,T淋巴细胞，细胞毒性;,表位;,预测；序列分析,0引言,1材料和方法,2结果

     Prediction and analysis of HLAA2restricted CTL epitopes derived from the tumor antigen MAGEA subfamily

    ZHANG XiuMin，SUI YanFang，LUO ErPing，LI ZengShan，HUANG YaYu，SI ShaoYan

    1Department of Pathology, School of Basic Medicine, 2Department of Military Medical Equipment & Metrology, School of Biomedical Engineering, Fourth Military Medical University, Xian 710033, China

    【Abstract】AIM： To predict the HLAA2restricted cytotoxic T lymphocyte (CTL) epitopes of tumor antigen MAGEA subfamily so as to provide appropriate CTL epitope for tumor immunotherapy. METHODS: The CTL epitopes of tumor antigen MAGEA subfamily were predicted by SYFPEITHI prediction method combined with the polynomial method. The amino acid sequence and the candidate CTL epitopes of the member of MAGEA subfamily were analyzed by DNAstar software. RESULTS: Fifty HLAA2restricted CTL epitope candidates (nonamers) derived from the tumor antigen MAGEA subfamily were selected and some epitopes were highly similar or completely identical. CONCLUSION: The combination of SYFPEITHI prediction method and polynomial method can improve the prediction efficiency and accuracy. Analyzing the homology of CTL epitopes and finding common epitopes help to develop some promising antigen peptide tumor vaccines.. ......

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