(广东医学院附属医院, 广东 湛江 524001)

    摘 要：目的：观察曲美布汀加喜普妙治疗功能性消化不良的疗效。方法：154例FD患者随机分为两组，观察组81例，给予曲美布汀胶囊及喜普妙联合用药治疗；对照组73例，单用曲美布汀治疗。比较观察两组的上腹胀满、餐后饱胀、早饱等症状的变化。结果：观察组对照组用药4周后临床主要症状均明显缓解(P<0.01或0.05)；除呕吐及上腹部疼痛外，其他症状消失率观察组均优于对照组。观察组治疗总有效率为91.3%，对照组为75.3%，两组相比，差异有显著性意义(P<0.05)。两组患者均无严重的不良反应。结论：曲美布汀联合喜普妙治疗FD疗效好，耐受性好，是一种可靠可行的治疗FD的方案。

    关键词： 消化不良； 功能性； 曲美布汀； 喜普妙

    Observing the Effect of Trimebutine Combined Citalopran on the Functional Dyspepsia

    FENG Yu-zhen, ZHU Bin, WU Ling-da

    (The Affiliated Hospital to Guangdong Medical College, Guangdong Zhanjiang 524001, China)

    Abstract： Objective： To study the effect of Trimebutine and Citalopram in the treatment of functional dyspepsia(FD). Methods： 154 FD paitients were randomly divided into two groups. The observation group(n=81) were given 100mg Trimebutine (3 time a day ) and 20mg Citalopram (once a day ) while the control group (n=73) were given 100mg Trimebutine (3 time a day ) ,for 4 weeks . Clinical symptoms were compared. Results：The main clinical symptoms in both groups were significantly relieved after 4-week treatment (P<0.011 or 0.05) . The other symptoms except vomiting and upper abdominal pain disappeared more completely in observation group than in control group. The total effective rates were 91.3% and 75.3% in observation group and contrl group, respectively. The difference between groups was significant (P<0.05). There was no severe side effect in both groups. Conclusion： The therapeutic effect of Trimebutine combined with Citalopram in treating FD is satisfactory and safe. ......