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阻塞性睡眠呼吸暂停综合征患者血清瘦素水平与胰岛素抵抗的关系
http://www.100md.com 《第四军医大学学报》 2005年第15期
阻塞性睡眠呼吸暂停综合征,,阻塞性睡眠呼吸暂停综合征;瘦素;胰岛素抗药性;呼吸暂停低通气指数;多导睡眠图,0引言,1对象和方法,2结果
     Relationship of leptin and insulin resistance in patients with obstructive sleep apnea syndrome

    XU JianPing, ZHANG BingFang, QIU JianHua, WU ChangGui

    1Department of Respiratory Diseases, 2Department of Otorhinolaryngology, Xijing Hosptial, Fourth Military Medical University, Xian 710033, China

    【Abstact】 AIM: To explore the relationship between serum leptin level and insulin resistance in patients with obstructive sleep apnea syndrome (OSAS). METHODS: Polysomnography was performed in all the enrolled cases, which were divided into four groups by body mass index (BMI) and apnea hypopnea index (AHI): group A obese OSAS (BMI≥27, AHI≥5), group B nonobese OSAS (BMI<25, AHI≥5), group C simple obese (BMI≥27, AHI<5) and group D normal control (BMI<25, AHI<5). Fasting plasma glucose (FPG) levels were measured by glucoseoxidase, fasting insulin (FINS) and fasting leptin levels were measured by radioimmunoassay. RESULTS: ①The serum insulin levels in groups A, B and C [(15.6±3.6), (11.7±2.3), (11.3±2.5) mU/L] were higher than that of group D [(9.1±1.8) mU/L, P<0 01] and the insulin level in group A was higher than those in groups B and C(P<0.01). ②The serum leptin levels in groups A, B and C [(6.6±1.4), (4.7±0.9), (4.2±0.7) μg/L] were higher than that in group D [(3.4±1.0) μg/L, P<0.05-0.01] and the leptin level in group A was higher than those in groups B and C(P<0.01). ③The HOMAIR in groups A, B and C(4.0±1.4, 3.0±0.8, 2.8±0.6)was higher than that in group D (2.1±0.6) (P<0.05-0.01) and HOMAIR in group A was higher than those in groups B and C(P<0.01). ④The leptin levels in the OSAS patients were obviously correlated with BMI, insulin and HOMAIR. CONCLUSION: Fasting plasma leptin level is closely related with the insulin resistance in patients with OSAS. ......

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