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大鼠弥漫性脑损伤后Homer蛋白的表达及其意义
http://www.100md.com 《第四军医大学学报》 2005年第24期
弥漫性脑损伤,,Homer;免疫印迹法;弥漫性脑损伤;大鼠,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Expression of Homer after diffuse brain injury in rats and its significance

    SHI TieJun, FEI Zhou, ZHANG Xiang, HUANG WeiDong, LIANG JingWen, SONG Lei

    PLA Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To study the expression and significance of Homer in diffuse brain injury(DBI)of rat in vitro. METHODS: One hundred and five SD rats, weighing(300±25)g, were randomized to normal, shamoperated and DBI groups. The Marmarou rats were applied to DBI group and the shamoperated group was treated as DBI group except for “free fall” attack. The rats main brain areas and nuclei were taken to detect for Homer by immunoblotting at 0.5, 1, 6, 12, 24, 72 and 168 h after injury respectively. RESULTS: Homer1a was positive in DBI group from 0.5 h to 168 h after injury but no Homer1a was observed in normal group and shamoperated group. Homer1b/c, Homer2a/b and Homer3 were present in the normal, shamoperated and DBI groups. CONCLUSION: There is a significant change in Homer1a expression before and after injury, but there is no significant change in Homer1b/c, Homer2a/b and Homer3 levels, which indicates that Homer1a is involved in the neuronal injury and may protect neurons from insults. ......

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