Clinical significance of plasma von Willebrand factor (vWF) and von Willebrand factor propeptide (vWFª²pp) and plasminogen system detection in chronic hepatitis patients

    HAN Jiª²Ju, WEI Ran, LI Zhen, REN Daoª²Ling, WU Yaª²Ping, WANG Zengª²Xian, CHEN Bin

    1Institute of Basic Medicine, Taishan Medical College, 2Taian City Central Hospital, Taian 271000, China, 3Department of Hematology, University Medical Center Utrecht, 3523 XC The Netherlands

    ¡¾Abstract¡¿ AIM: To investigate the plasma level of vWFª²pp, vWF, tPA, PAIª²1 and Dª²Dimer in hepatitis patients and evaluate their clinical significance. METHODS: The levels of vWFª²pp, vWF, tPA, PAIª²1 and Dª²Dimer in hepatitis groups and control groups were determined by Sandwich enzyme linked immunoª²sorbent assay (ELISA). RESULTS: The levels of vWFª²pp were significantly different between hepatitis patients [(1.54¡À1.83) mg/L] and control groups [(0.43¡À0.09) mg/L, P <0.01]; The level of vWF in hepatitis patients was (60.30¡À99.81) mg/L and (11.27¡À5.34 )mg/L in control group, and they were significantly different (P <0.05); All the levels of Dª²Dimer, PAIª²1 and tPA were significantly different between hepatitis patients and control group (P<0.01, P <0.05). vWFª²pp concentration showed significantly positive correlation with blood vWF and Dª²Dimer levels ( P<0.01) . There was obvious correlation between the level of tPA and PAIª²1 P <0.05. CONCLUSION: The plasma level of vWFª²pp, vWF , tPA , PAIª²1 and Dª²Dimer in hepatitis patients may reflect vessel wall injury, which might influence coagulation and fibrinolysis in vivo from different aspects. These observation might be important for diagnosis and prognosis of the disease. ......