Hemostatic effect and blood coagulation function of hemocoagulase in spinal operations

    LIU Qiª²Ning, PANG Xiaoª²Hong, KE Baoª²Jun

    1Department of Anesthesiology, First Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China, 2Department of Anesthesiology, Xi¬ðan Electroª²machinery Groups¬ð Hospital of China Western Electricity Group, Xi¬ðan 710077, China, 3Department of Anesthesiology, Maternity and Child Health Care Hospital, Luonan County, Shaanxi Province, Luonan 726100, China

    ¡¾Abstract¡¿ AIM: To study the hemostatic effect and blood coagulation function of hemocoagulase in spinal operations. METHODS: One hundred ASA physical status ¢ñor ¢òpatients (M 54, F 46, age 18ª²65 years) undergoing selective spinal surgeries were selected and randomly divided into two groups of 50 each: hemocoagulase group and saline group as control. Before operation, hemocoagulase (3 kU) was injected in hemocoagulase group and normal saline was injected in control group. The data compared between the two groups were prothrombin time (PT), thrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), blood platelet (PLT), bleeding volume during operation, transfusion volume and drainage volume 24h after operation. RESULTS: There was no significant difference in age, mass and operation time between the two groups (P>0.05). The PT, TT and APTT increased significantly after operation in control group (P<0.05). There was no significant difference in hemocoagulase group before and after operation. There was significant difference between the two groups (P<0.05). The bleeding and transfusion volume during operation and the drainage volume 24h after operation in hemocoagulase group were less than that in control group, with significant difference between the two groups (P<0.05). CONCLUSION: Hemocoagulase can reduce the bleeding, transfusion volume and drainage volume 24h after operation in spinal operation with no significant effect on the coagulation function. ......