Clinicopathologic significance of expression of CD34 and vascular endothelial growth factor and microvessel density in human thyroid tumor

    WANG Wenª²Yong£¬TANG Hongª²Wei£¬ZHANG Zhiª²Pei, GAO Yanª²Hong£¬HAN Bin£¬MA Fuª²Cheng£¬ZHAO Yiª²Ling

    1Department of Pathology, School of Basic Medicine, 2Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China, 3Department of Gastroenterology, General Hospital of Chinese People¬ðs Armed Police Forces, Beijing 100039, China

    ¡¾Abstract¡¿ AIM: To study clinicopathologic significance of microvessel density (MVD) and the expression of CD34 and vascular endothelial growth factor (VEGF) in human thyroid tumors. METHODS: Expression of CD34 and VEGF in thyroid tumor tissues of 68 cases was determined by immunohistochemistry method. MVD counting and semiª²quantitation of VEGF expression were performed and analyzed in conjunction with the clinicopathological features of human thyroid tumors. RESULTS: The rate of positive VEGF expression was 74% (50/68) in the patients with thyroid tumors. MVD was significantly higher in positive VEGF expression thyroid tumors than in negative VEGF expression thyroid tumors (P<0.05). CONCLUSION: MVD and expression of VEGF remarkably increase in thyroid tumors. The expression of VEGF is a good indicator in assessing the prognosis of patients with thyroid tumors. ......