Changes of sICAMª²1 and sHLAª²¢ñin endometriosis and its significance

    ZHANG Rong, LUO Ruoª²Yu

    Department of Gynecology and Obstetrics, People¬ðs Hospital, Wuhan University, Wuhan 430060, China

    ¡¾Abstract¡¿ AIM: To investigate the relationship between endometriosis (EMs) and the levels of soluble intercellular adhesion moleculeª²1 (sICAMª²1) and soluble human leucocyte antigenª²1 (sHLAª²¢ñ). METHODS: Thirty serum and 30 peritoneal fluid (PF) of patients with EMs (test group) and 30 serum and 30 peritoneal fluid of patients without EMs (control group) were studied. The levels of sICAMª²1 and sHLAª²¢ñwere detected by enzymeª²linked immunosorbent assay (ELISA). RESULTS: ¢Ù Significantly higher levels of sICAMª²1 in serum and PF were observed in patients with EMs compared with those in controls (P©‚0.05). ¢Ú The levels of sICAMª²1 in serum and PF were significantly different and the levels in earlyª²stage EMs group were higher than those in advanced group (P©‚0.05). ¢Û Serum sHLAª²¢ñ cevel was lower in EMs group (P©‚0.05) but the level in earlyª²stage EMs group was higher than that in advanced group (P©‚0.05). ¢Ü There were no statistically significant differences in the levels of sHLAª²¢ñin PF between the patients and the controls (P©ƒ0.05). CONCLUSION: Changes of sICAMª²1and sHLAª²¢ñmay play a role in the genesis of endometriosis. ......