神经病理性痛__(期刊论文)

丙戊酸钠对大鼠损伤背根节神经元异位自发放电的抑制作用

http://www.100md.com 《第四军医大学学报》 2005年第20期

神经病理性痛,,神经节，脊；异位自发放电；丙戊酸；神经病理性痛,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of sodium valproate on ectopic spontaneous discharge of injured dorsal root ganglion neurons in rats

    YANG RuiHua, XING JunLing, HU SanJue

    Institute of Neuroscience, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the effect of sodium valproate on ectopic spontaneous discharge (ESD) in injured dorsal root ganglion (DRG) neurons. METHODS: Single dorsal root fiber was separated, the ESD conducted from injured DRG neurons was recorded and the effects of different concentrations of sodium valproate were observed. RESULTS: Different concentrations of sodium valproates decreased the number of ESD in a dosedependent manner. CONCLUSION: The administration of sodium valproate inhibits the number of ESD from injured DRG neurons. This may lay a foundation for using sodium valproate peripherally as analgetic.

    【Keywords】 ganglia, spinal; ectopic spontaneous discharge; valproic acid; neuropathic pain

    【摘要】目的：探讨丙戊酸钠(sodium valproate, VPA)对损伤背根节神经元异位自发放电的影响及其时间和剂量关系. 方法：分离背根单纤维 ......

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