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卵巢上皮性癌PTEN和PCNA的表达
http://www.100md.com 《第四军医大学学报》 2005年第19期
卵巢肿瘤,,卵巢肿瘤;PTEN基因;增殖细胞核抗原;表达,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Expression and significance of PTEN and PCNA in ovarian epithelial carcinoma

    HE YinFang, WU ZhiYu, HAN QingWei

    1Department of Obstetrics and Gynecology,Central Hospital of Shanglu District, Shaanxi 726000, China, 2Department of Obstetrics and Gynecology,521 Hospital of Industrial Ministry of Weapons, Xian 710065, China

    【Abstract】 AIM: To investigate the expression of PTEN and PCNA in ovarian epithelial carcinoma and their relationship with clinicopathology. METHODS: The expression of PTEN and PCNA in 128 cases of ovarian epithelial carcinoma, 46 cases of benign tumors and 20 cases of normal ovarian tissue were determined and compared by SABC immunohistochemical method. RESULTS: The positive rate of PTEN in ovarian carcinoma tissues was lower than that in benign tumor tissues and normal ovarian tissues and the expression trend of PCNA was opposite to that of PTEN (P<0.05). In ovarian carcinoma, a negative correlation between expression PTEN and PCNA was observed (r=-0.511, P=0.000). The expression of PTEN and PCNA was relative to the pathological stages and clinical stages. CONCLUSION: The downregulation of PTEN expression in ovarian carcinoma is associated with the genesis and development of ovarian carcinoma and the upregulation of PCNA expression is associated with the proliferation and pathological differentiation of the tumor tissues. ......

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