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编号:10949084
拉米夫定联合干扰素对慢性乙肝的疗效观察
http://www.100md.com 《第四军医大学学报》 2005年第21期
肝炎,,肝炎,乙型,慢性;,治疗;拉米夫定;干扰素,0引言,1对象和方法,2结果,3讨论,【参考文献】
     Observation of therapeutic efficacy of lamivudine combined with alpha interferon in patients with chronic hepatitis B

    DUAN WenBin,WANG BoLiang, ZHOU XiaoPing,ZHONG YueXia

    1Department of Emergency, Tangdu Hospital,Fourth Military Medical University,Xian 710038,China, 2Department of Infection, PLA First Hospital ,Lanzhou 730030,China

    【Abstract】 AIM: To study the therapeutic efficacy of lamivudine combined with alpha interferon in patients with chronic hepatitis B and to find a new approach to control the disease. METHODS: Eighty chronic hepatitis B patients with HB VDNA and HBeAg positive were divided into two groups: LAM+IFN group treated with lamivudine and alpha interferon for 12 months and LAM group treated with lamivudine alone for 12 months. RESULTS: The therapeutic effect on YMDD mutation in the group with lamivudine and IFNα1b was significantly better than that in the group with lamivudine alone(P<0.01). CONCLUSION: Lamivudine combined with alpha interferon has better therapeutic efficacy in patients with chronic hepatitis B. ......

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