HSPª²peptide complex vaccine in preventing postoperative recurrence of hepatocarcinoma: 32 cases report

    ZHAO Ziª²Lin, YAN Li, CUI Jianª²Dong, SHI Jianª²Guo, LONG Guiª²Ning

    1Department of Oncology, PLA 303 Hospital, Nanning 530021, China, 2Institute of Oncology, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the effects of heat shock proteinª²peptide complex as antiª²tumor vaccines in preventing the postoperative recurrence of primary liver cancer (PLC). METHODS: The cases reviewed were 32 cases of hepatocarcinoma treated post operatively with HSPª²peptide complex vaccine. The CD3+, CD8+, CD4+/CD8+, NK activity and the levels of serum SILª²2R were tested before and after treatment and 1ª², 2ª² and 3ª²year survival rates were analyzed. RESULTS: CD3+, CD8+ and the activity of NK cells increased and CD4+/CD8+ decreased significantly compared with those of controls (P<0.05). The 3ª²year survival rate was 68.8% in the treatment group compared with 37.5% in controls (P<0.05). CONCLUSION: HSPª²peptide complex vaccine may improve immunity and prevent postoperative recurrence of PLC and prolong patients¬ð survival time. ......