Effect of postoperative immuneª²enhanced enteral nutrition in patients with total gastrectomy

    ZHENG Jianª²Yong, WANG Weiª²Zhong, GUAN Wenª²Xian, CHEN Dongª²Li, ZHANG Chongª²Guang

    1Department of Gastrointestinal Surgery, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China, 2Department of Surgery, General Hospital, Beijing Armed Police Corps, Beijing 100027, China

    ¡¾Abstract¡¿ AIM: To study the effect of postoperative immuneª²enhanced enteral nutrition support on the nutritional status, immune function and inflammatory responses in patients with total gastrectomy. MEHTODS: Fiftyª²two gastric cancer patients with total gastrectomy were randomly divided into 2 groups: Enteral nutrition group (EN group, n=26) and immuneª²enhanced enteral nutrition group (experiment group, n=26). Calorie and nitrogen of the same quantity were provided for both groups from the first day after surgery. The patients in EN group received conventional enteral nutrition support with Nutrison and the patients in experiment group received immuneª²enhanced enteral nutrition support with Stresson for 7 d, respectively. The levels of total protein, albumin, prealbumin, IgG, IgA, IgM, CD3, CD4, CD8, CD4/CD8, ILª²2 and TNFª²¦Á were measured preoperatively and on day 1 and 8 after operation. RESULTS: The total protein, albumin and prealbumin had no difference between the two groups. On the 8th day after operation, the levels of IgG, IgA, IgM, CD3, CD4 and CD4/CD8 were significantly higher in experiment group than those in EN group (P<0.05), while TNFª²¦Á was significantly lower in experiment group than that in EN group (P<0.05). CONCLUSION: Early postoperative immuneª²enhanced enteral nutrition support can improve the immune function of gastric cancer patients with total gastrectomy and alleviate inflammatory responses. ......