溃疡性结肠炎患者外周血单个核细胞中Foxp3 mRNA的表达水平
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李永哲, 孙可歆, 赵 臣
溃疡性结肠炎;转录因子Foxp3;外周血单个核细胞李永哲,孙可歆,赵臣.溃疡性结肠炎患者外周血单个核细胞中Foxp3mRNA的表达水平. 世界华人消化杂志2006;14(8)810-813
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李永哲, 孙可歆, 赵臣,中国医学科学院中国协和医科大学、北京协和医院检验科 北京市 100730国家自然科学基金资助项目, No. 30471617
国家高技术研究发展技划(863计划)重大专项基金资助项目, No. 2002AARZ2011
通讯作者:李永哲, 100730, 东城区帅府园1号, 中国医学科学院中国协和医科大学、北京协和医院检验科.
yongzhelipumch@yahoo.com.cn
电话:010-65295416 传真:010-65295416
收稿日期:2006-01-11 接受日期:2006-02-08
Expression of Foxp3 mRNA in peripheral blood monocytes of patients with ulcerative colitis
Yong-Zhe Li, Ke-Xin Sun, Chen Zhao
Yong-Zhe Li, Ke-Xin Sun, Chen Zhao, Department of Laboratory, Hospital of Peking Union Medical College, Beijing 100730, China
Supported by National Natural Science Foundation of China, No. 30471617, and the Key Special Foundation of National 863 Project, No. 2002AARZ2011
Correspondence to: Yong-Zhe Li, Peking Union Medical College Hospital, Beijing 100730,China. yongzhelipumch@yahoo.com.cn
Received: 2006-01-11 Accepted: 2006-02-08
Abstract
AIM:To investigate the level of Foxp3 mRNA in the peripheral blood monocytes (PBMCs) of patients with ulcerative colitis (UC), and its relationship with activity of UC.
METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) was used to examine Foxp3 mRNA expression in the PBMCs from 22 cases with UC in active stage, 20 cases at stable stage, and 30 normal controls.
RESULTS: Foxp3 mRNA expression was lower in patients with UC at active stage than that in the controls (1.58 ± 0.31 vs 3.27 ± 0.40, P < 0.05), while Foxp3 mRNA expression in UC at stable stage was not significantly different from that in the controls (P = 0.104). The level of Foxp3 mRNA in the PBMCs in active UC was negatively correlated with the Walmsley renal scoring (r = -0.756, P = 0.000).
CONCLUSION: Foxp3 mRNA expression in the PBMCs may be involved in the pathogenesis and activity of UC.
Key Words: Ulcerative colitis; Foxp3; Peripheral blood monocytes ......
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