妊娠和分娩中子宫平滑肌及胎盘内皮素受体A表达的初步探讨
妊娠,,分娩发动；内皮素受体；免疫组化,1资料与方法,2结果,3讨论,参考文献
【摘要】 目的 探讨临产前、后子宫平滑肌细胞及胎盘滋养细胞内皮素受体A(ETA)的表达变化。方法 应用免疫组化方法结合计算机图像分析技术分析60例足月妊娠剖宫产产妇子宫下段平滑肌细胞及胎盘滋养细胞ETA的表达，观察临产前、后两组的表达强度。结果 临产组子宫平滑肌细胞及胎盘滋养细胞ETA的表达显著强于未临产组，差异有显著意义(P<001)。结论 ETA可能通过参与调节子宫平滑肌收缩和局部前列腺素的合成参与分娩发动。【关键词】 分娩发动；内皮素受体；免疫组化
Expression of ETA in myometrium and placenta during pregnancy and parturition
LIU Zhiqiang WANG Yuqian ZHANG Hongtao
Department of Obstetrics & Gynecology,Affiliated Hospital of Binzhou Medical College,Binzhou 256603
【Abstract】 Objective To study the expression of endothelin receptor A (ETA) in myometrium and placental trophoblastic cells before and after labor onset.Methods Sixty women at term pregnancy were devided into two groups according to whether they were in labor or not.Both groups included thirty women and they were all delivered by cesarean section.Expression of ETA in myometrium and placental trophoblastic cells were detected by immunohistochemical SABC method and computerized quantitative image analysis.Results The expression of ETA in myometrium and placental trophoblastic cells in the group at labor onset was significantly higher than that in the group not at labor (P<001).Conclusion ETA may be involved in the initiation of parturition by regulating the contraction of myometrium and improving prostaglandins level. ......
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