Relationship between autoantibodies against AT1 and ¦Á1 receptors and hypertension with renal failure

    ZHAO Linª²Shuang, LIAO Yuª²Hua, WANG Min, ZHOU Ziª²Hua, XIANG Guangª²Da,HOU Jie, YUE Ling£¬ XU Lin

    1Department of Endocrinology, Wuhan General Hospital, Guangzhou Military Area Command, Wuhan 430070, China, 2Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

    ¡¾Abstract¡¿ AIM: To study the role of the autoantibodies against angiotensin ¢òtype 1 receptor (AT1 receptor) and ¦Á1ª²adrenergic receptor(¦Á1 receptor) in the development of hypertension combined with renal failure. METHODS: The epitopes of the second extracellular loop of AT1 receptor (165-191) and ¦Á1 receptor (192-218) were synthesized and used respectively to screen sera autoantibodies from patients with hypertension and renal failure (n=61), patients with hypertension but without renal failure (n=60) and healthy blood donors (n=40, control) by ELISA and to screen the hormones of nerve and endocrine by RIA and by FIA. RESULTS: The positive rates of the autoantibodies against AT1 receptor (59.0%)and ¦Á1 receptor (54.1%) in patients with hypertension and renal failure were higher than those in patients with hypertension but without renal failure (13.3% and 10.0% respectively) (P<0.01) and they were also higher than those of healthy donors (10.0% and 7.5% respectively) (P<0.01). The hormones of nerve and endocrine (PRA, Ang¢ò, ALD, E, NE) in patients with hypertension and renal failure were higher than those of patients with hypertension but without renal failure and they were also higher than those in healthy donors (P<0.05, P<0.01). CONCLUSION: Autoantibodies against AT1 receptor and ¦Á1 receptor may play some important roles in the pathogenesis of the hypertension combined with renal failure and activate accordingly the hormones of nerve and endocrine system in patients with the disease. ......