Dynamic changes of brain natriuretic peptide in heart failure with carvedilol

    QIAO Yanª²Guo, LIU Hui, HAN Ying, HUANG Zhiª²Gang

    1First Department for Senior Officials, General Hospital of Chinese People¬ðs Armed Police Forces, Beijing 100039, China, 2Department of Internal Medicine, Hospital of NO.8640 Unit, Chinese People¬ðs Armed Police Forces,Dingzhou 073000,China, 3Department of Internal Medicine, PLA 305 Hospital, Beijing 100017, China

    ¡¾Abstract¡¿ AIM: To investigate the dynamic changes of brain natriuretic peptide(BNP) in chronic congestive heart failure (CHF)with carvedilol and to explore the effect of carvedilol on the endocrine secretion of heart . METHODS: One hundred thirty cases of chronic CHF were subjected to the study, 68[47 men and 21 womem, average age (58¡À12) years] as a carvedilol group; 62[42 men and 20 women, average age (57¡À11) years] as a control group . Plasma levels of BNP were meaª²sured by IMRA method in these patients before and 6 months after treatment. RESULTS: Plasma levels of BNP was significantly reduced in carvedilol group compared with control group (P<0.01). CONCLUSION: Carvedilol ,non-selective ¦Â receptor blocker, can reduce plasma level of BNP in chronic heart failure, and improve the endocrine function of heart, thus bringing a favourable prognosis to CHF patients. ......