关键词: 肝细胞癌;D-二聚体;γ-纤维蛋白原多肽

    摘 要:目的 探讨在肝细胞癌(HCC)患者中D-二聚体和γ-纤维蛋白原多肽(FGG)的生化改变及其临床意义. 方法 采用酶联免疫吸附反应定量检测了57例HCC患者的血浆D-二聚体，通过RT-PCR分析了编码FGG的mRNA在病变组织的转录水平. 结果 HCC患者的血浆D-二聚体含量(0.81±0.21)mg·L-1 显著高于正常对照组(0.15±0.07)mg·L-1 (P<0.01);在各临床分期之间D-二聚体含量差别非常明显，尤以转移期癌D-二聚体测定值的升高最为显著.FGG的mRNA在癌组织中的表达较癌旁非癌组织明显上调，同时还发现这种表达增强与淋巴结转移相关. 结论 D-二聚体的异常增高、FGG mRNA的高表达与HCC的临床分期和淋巴结状况关系密切.

    Changes of D┐dimer and FGG in hepatocellular car┐cinoma patients

    FAN Bing-Lin ZHU Wu-Ling ZOU Guo-Lin

    1 College of Life Sciences，Wuhan University，Wuhan430072，China，

    2 Department of Basic Medicine，Xinxiang Medical College，Xinxiang453003，China

    Keywords:hepatocellular carcinoma;D-dimer;gamma fib-rinogen polypeptide

    Abstract:AIM To investigate the biochemical changes of D-dimer and gamma fibrinogen polypeptide(FGG)，and their clinical significance in hepatocellular carcinoma(HCC).METHODS Plasma D-dimer levels were quantitated in57patients with HCC by using ELISA ......