关键词: 急性肺损伤;乙酰半胱氨酸

    摘 要:目的 观察乙酰半胱氨酸对急性肺损伤的防治作用. 方法 大耳白兔24只，随机分为对照组(n=8)，致伤组(n=8)，乙酰半胱氨酸治疗组(n=8).致伤组经颈静脉注入脂多糖(LPS，1mL·kg-1 );对照组经颈静脉注入生理盐水(1mL·kg-1 );治疗组经颈静脉在注入脂多糖(LPS，1mL·kg-1 )前2min，经颈静脉注入乙酰半胱氨酸(300mg·kg-1 ).测定各组肺动脉压、动脉血氧分压、外周血白细胞计数、肺泡灌洗液NO2- 浓度、肺系数(肺湿质量/体质量)及肺湿/干比. 结果 治疗组肺动脉压及NO2- 浓度与致伤组有显著差别(P<0.01)，氧分压较致伤组明显改善(P<0.01)，肺系数和肺湿/干比显著低于致伤组(P<0.01)，外周血白细胞高于致伤组(P<0.01). 结论 乙酰半胱氨酸对急性肺损伤有一定的防治作用.

    Preventive effect of N┐acetyl┐L┐cysteine against acute lung injury

    MU De-Guang，LI Huan-Zhang

    Department of Respiratory Disease，Xijing Hospi-tal，Fourth Military Medical University，Xi'an710033，China

    Keywords:acute lung injury;N-acetyl-L-cysteine

    Abstract:AIM To observe the preventive effect of N-acetyl-L-cysteine against acute lung injury.METHODS 24New Zealand rabbits were randomly divided into three groups:control group(n=8)，injury group(n=8)，treat-ment group(n=8).The injury group were endotoxin(1mL·kg-1 );the control group were given injection of normal saline(1mL·kg-1 ) ......