关键词: 肺结核;抗结核治疗;肝功能损害;HBV携带者

    摘 要:目的 对比HRZE(S)和HLAMKO两种抗结核化疗方案对肝脏功能的影响，探讨抗结核治疗过程中HBV携带与肝功能损害的关系. 方法 选择肺结核患者217例，随机分成HRZE(S)和HLAMKO两个治疗组，于治疗前和治疗后每2wk检测肝功能，并观察临床症状，比较两种化疗方法对肝功能的影响;同时分析47例合并HBV携带者肝功能的变化. 结果 217例患者中，不同程度肝功能损害者共66例(30.4%)，应用HRZE(S)方案组53例(46.1%)，明显高于HLAMKO方案组13例(12.7%);肺结核合并HBV携带者发生肝功损害者26例(55.3%)，明显高于非HBV携带者40例(23.5%). 结论 HLAMKO方案对肝功能的损害小;对合并HBV携带患者应选肝损害小的治疗方案，同时应用保肝药物.

    Comparison of the effects two treatments for tuber┐culosis on liver function in patients with pulmonary tuberculosis

    CHEN Lin JIA Zhan-Sheng FU En-Qing XIE Yong-Hong CHU Dong-Ling LIU Tong-Gang JING Fa-Guang

    1 Department of Respiratory Disease，

    2 Department of Infectious Diseases，Tangdu Hospital，Fourth Mili-tary Medical University，Xi'an710038，China

    Keywords:pulmonary tuberculosis;anti-TB therapy;liver dysfunction;HBV carrier

    Abstract:AIM To compare the effects of two treatments for tuberculosis on liver function in patients with tuberculo-sis，and to study the differences in liver dysfunction between hepatitis B virus carriers(HBV).METHODS 217patients with tuberculosis were divided into HRZE(S)and HLAMKO treatment groups ......