关键词: 失血性休克;再灌注损伤;高氧平衡盐液

    摘 要:目的 观察高氧平衡盐液对防治家兔失血性休克再灌注损伤效果. 方法 家兔休克90min后回输放血总量1/3的血液，同时分别输注平衡盐液(对照组，n=10)及高氧平衡盐液(治疗组，n=10). 结果 再灌注后治疗组平均动脉压(MAP)迅速上升，于再灌注后3h显著高于对照组，CVP及HR较快恢复至休克前的水平，血清丙二醛(MDA)呈下降趋势.而对照组再灌注后MDA显著上升，MAP进行性下降，反映机体组织遭受了再灌注损伤. 结论 高氧平衡盐液能迅速逆转失血性休克血流动力学改变，有效防治休克再灌注损伤.

    Preventive and curative effect of hyperoxia saline solution on reperfusion injury caused by bleeding shock

    SUN Xu-De CHAI Wei WANG Yu MA Jia-Hai GAO Chang-Jun ZHANG Gui-He YANG Yong-Hui ZHAO Hui XU Li-Xian

    1 Department of Anesthesiology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China，

    2 Department of Outpatient，General Staff Administration of Chinese PLA，Beijing100035，China，

    3 Department of Anesthesiology，Qindu Stomatological College，Fourth Military Medical University

    Keywords:bleeding shock;reperfusion injury;hyperoxia balanced saline solution ......