【摘要】 目的 观察钩藤散浸膏对衰老模型小鼠智力、乙酰胆碱酯酶(ACHE)、抗氧化酶(SOD)、自由基(MDA)的影响，探讨其抗衰老作用及机制。方法 小鼠随机均分为6组，除正常对照组外，各组每天皮下注射D-半乳糖(0.05g/kg)，连续注射6周。从注射的第7天开始，3个实验组同时灌胃高、中、低剂量的钩藤散浸膏，阳性对照组灌以维生素E(0.05g/kg)模型对照组与正常对照组每天灌胃等量的蒸馏水，连续给药5周后测定小鼠的训练成绩、记忆成绩及血清SOD、ACHE和脑组织MDA的含量变化。结果 实验组的训练成绩显著(P<0.05)，测试成绩极显著(P<0.01)好于、血清SOD、ACHE活力极显著(P<0.01)高于、脑MDA含量极显著(P<0.01)低于模型对照组；与正常组比，除ACHE偏高外，其余各指标相近。结论 钩藤散能提高抗氧化能力，降低自由基含量，增强胆碱能神经系统功能，从而防止衰老。

    【关键词】 D-半乳糖；钩藤散；衰老；小鼠

    The effect of Goutengsan extract on subacutely aging model in mice

    HUANG Hou-cai，HU Yuan-liang，HU Chun-ping，et al.Jiangsu Provincial Academy of Traditional Chinese Medicine，Nanjing 210028，China

    【Abstract】 Objective To observe the effects of Goutengsan extract on memory，malondiadehyde(MDA)，superoxide dismutase(SOD)，ACHE in mice to study therapeutic effects and mechanism of Goutengsan on aging model.Methods Mice were randomly divided into 6 groups. All groups，except the control，were administrated (ip) with D-galactose (0.05g/kg) for successive 6 weeks. The 3 experimental groups were administrated (ig) with high ......