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编号:10965591
双灵固本散对人胃癌细胞血管生成相关基因表达的调节
http://www.100md.com 《中华医药杂志》 2006年第3期
双灵固本散,,灵芝(Ganoderma,lucidum,Karst);双灵固本散;血管生成;胃癌,1材料与方法,2结果与讨论,【参考文献】
     【摘要】 本课题用人血管生成基因芯片对双灵固本散处理前后人胃癌细胞BGC-823细胞血管生成相关基因的表达水平变化进行定量研究。在检测到的8个表达有明显改变的血管生成相关基因中,7个明显升高,1个明显降低。几个血管生成抑制基因表达的显著升高,说明该药物可能对肿瘤产生抑制并促进肿瘤细胞分化,但其对肿瘤组织的血管生成的具体影响, 还有待进一步的活体实验来证明。

    【关键词】 灵芝(Ganoderma lucidum Karst);双灵固本散;血管生成;胃癌

    The regulation of sunrecome(Shuanglinggubensan) on the expression of angiogenesis related genes in human gastric tumor cell

    WANG Tao,WU Hou,TANG Li,et al.

    School of Life Sciences of Shanghai University, Shanghai 200436,China

    【Abstract】 In this research work, the change of the expression of the angiogenesis related genes in cultured gastric tumor cell BGC-823 after treatment with a commercial traditional Chinese medicine product -Sunrecome(Shuanglinggubensan) was measured, by using angiogenesis related gene array (purchased from Superarray). And the drug treatment up-regulated the expression of 7 angiogenesis related genes markedly, while the expression of 1 angiogenesis related gene was down-regulated.The Sunrecome(Shuanglinggubensan) can prevent the angiogenesis of gastric tumor, but it should be proved by research in vivo. ......

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