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编号:10965694
斯奇康治疗小儿反复呼吸道感染的临床观察
http://www.100md.com 《中华现代儿科学杂志》 2005年第12期
斯奇康,,斯奇康;反复呼吸道感染;免疫,1资料与方法,2疗效观察,3结果,4讨论
     【摘要】 目的 观察斯奇康(卡介苗多糖核酸,BCG-PSN)治疗小儿反复呼吸道感染(RRTI)的临床与免疫功能变化。方法 将于我院就诊的66例反复呼吸道感染的患儿随机分为2组,对照组常规给予抗感染及对症治疗,治疗组除给予同样治疗外,加斯奇康肌注,5mg/次,>7岁隔日1次,<7岁每周2次,疗程1个月。观察记录治疗前后临床及检测指标。结果 经斯奇康治疗后,患儿反复呼吸道感染的次数减少,感染时间缩短,症状减轻,有效率77.5%,与对照组相比,差异有极显著性(P<0.01)。经治疗后治疗组血中IgG、IgA、IgM浓度有增高,与对照组比较差异有极显著性(P<0.01)。结论 斯奇康能增强反复呼吸道感染的患儿机体免疫功能,减少感染次数,缩短感染时间。

    【关键词】 斯奇康;反复呼吸道感染;免疫

    Clinical observation of RRTI children treated by BCG-PSN

    ZHANG Yu-chan,CAO Wen-xia.Chengdu No.6 Peoples Hospital,Chengdu 610051,China

    【Abstract】 Objective To observe the clinical and immunological changes in RRTI children treated by BCG-PSN.Methods To divide 66 RRTI cases into two groups randomly.The control group:only routine treatment.The treatment group:besides give same treatment and add BCG-PSN intramuscular,5mg/once >7 years,every other day one time,<7 years,per week twice,treatment to duration one month.To record the clinical and immunologic laboratory results before and after treatment.Results The frequency of infection lessened,the duration shortened,the symptoms alleviated.Total effective rate 77.5%,as compared with control group P<0.01.After treatment,with the control group IgG,IgA,IgM levels have raised up,there are differences statistically between the two groups(P<0.01).Conclusion BCG-PSN can enhance the immunological function of RRTI children,lessen the frequency of infection,and shorten the infectious duration. ......

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