【摘要】 目的 了解再次放疗对鼻咽癌复发病人的治疗价值，并试图分析可能影响再放疗结果的因素。方法 2002年1月～2002年12月治疗的113例复发性鼻咽癌，所有的病人均接受外照射，其中51例加腔内放疗(192Ir)。结果 总的4年生存率、无瘤生存率、局控率分别是51.2%和48.3%和49.9%。分析了复发间隔期对于生存率、局控率和无瘤生存率的关系。观察了24例病例的初发及复发病灶的细胞凋亡发生情况，发现细胞凋亡数、分裂相数目差异无显著性。结论 复发性鼻咽癌的再放疗仍是相当有效，尤其是对于复发间隔期大于2年的病例。但在治疗方法上可考虑采用一些非常规的治疗方法。

    【关键词】 复发性鼻咽癌；再次放射治疗；复发间隔期

    Re-irradiation of recurrent nasopharyngeal carcinoma

    ZHANG ZHen-Ming， LING Xiao-Feng, Xie Li.

    MaoMing Farming Hosptial, Gaozhou 525200,China

    【Abstract】 Objective To evaluate the value of re-irradiation in recurrent nasopharyngeal carcinoma(NPC) and to analyze the factors influencing the re-treatment results.Methods One hundred and thirteen cases of recurrent NPC received radiation therapy during Jan.2002 to Dec.2002 in our hospital. All patients received external beam irradiation ,51 of them also received intracavitary brachytherapy_(192Ir).Results The overall 4-year survival rate,disase-free survival rate and local control rate 51.2%,48.3%,and 49.9%,respectively.Distant metastasis rate was 18.5%. Two cases with radiation brain necrosis and one case with fistula in hard plate have been observed. The relationship of interval of recurrence and the treatment results, including survival, local control, distant metastasis-free survival was analyzed. The conmparisons of histology, apoptosis index(AI) and mitosis index(MI) ofinitial lesions and recurrent lesions were found insignificant.Conclusion Our data show the efficacy of re-irradiation for trearment of recurrent NPC, especially in those cases with interval of recurrencel longer than 2 years. ......