重症肌无力__(期刊论文)

重症肌无力大鼠膈肌运动终板的形态学研究

http://www.100md.com 《第四军医大学学报》 2005年第2期

重症肌无力,,重症肌无力；乙酰胆碱酯酶；受体，胆碱能；运动神经肌肉终板；超微结构,0引言,1材料和方法,2结果,3讨论

     Research on morphological changes of end plates in diaphragm of experimental autoimmune myasthenia gravis rats

    LIU Rui1，3LI ZhuYi1，ZHANG Qi2，WANG GuiPing1，LIU JinPing3，JU Gong3

    1Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xian 710038,China,2Department of Stomatology, Hospital of Beijing General Armed Policeman Corps, Beijing 100039,China,3PLA Institute of Neurosciences, Fourth Military Medical University, Xian 710033,China

    【Abstract】 AIM： To study the pathological characteristics of the end plate on diaphragm in experimental autoimmune myasthenia gravis animal model by light microscopy and electron microscopy. METHODS: Passively transferred myasthenia gravis animal model was prepared by injection of acetylcholine receptor monoclonal antibody mAb35, and the ultrastructure of the end plates was studied by acetylcholinesterase histochemical technique. RESULTS: Myasthenia symptoms were induced in the experimental group. The end plates of diaphragm showed ultrastructural changes similar to those of myasthenia gravis patients but no change was found in the number of the end plates. No changes were observed in the control group. CONCLUSION: It is suggested that the ultrastructural changes of the end plates on diaphragm may result in the dyspnea in experimental autoimmune myasthenia gravis. ......

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