贲门腺癌__(期刊论文)

新疆90例贲门癌中IGFIR、 bcl2、PCNA的表达及其意义

http://www.100md.com 《新疆医科大学学报》 2006年第3期

贲门腺癌,,贲门腺癌；胰岛素样生长因子I受体(IGFIR)、细胞凋亡相关基因2(bcl2)及增殖细胞核抗原(PCNA),；不同民族；免疫组化,新疆90例贲门癌中IGFIR、bcl2、

     摘要: 目的：探讨胰岛素样生长因子I受体(IGFIR)、细胞凋亡相关基因2(bcl2)及增殖细胞核抗原(PCNA)的异常表达在新疆3个不同民族贲门癌发生发展中的作用及其病理生物学意义，为此病的防治提供实验资料。方法：应用免疫组化LSAB法检测90例贲门腺癌和21例非癌组织的IGFIR、bcl2、PCNA蛋白的阳性表达情况。结果：(1)IGFIR、bcl2蛋白、PCNA在90例贲门腺癌中的检出率分别为84.44%(69/90)、87.78%(79/90)、97.78%(88/90)，在贲门非癌良性组织中的阳性检出率分别为47.62%(10/21)、52.38%(11/21)、0%(0/21)。IGFIR、 bcl2、PCNA的阳性率在癌和非癌组织间均具有统计学的差异(P<0.01)。(2)哈萨克族(哈族)、维吾尔族(维族)、汉族各民族之间IGFIR、bcl2、PCNA阳性率的差异均无统计学意义(P>0.05)。(3)IGFIR、bcl2、PCNA在贲门腺癌不同分化程度中阳性率的差异均无统计学意义(P>0.05)。(4)贲门腺癌中bcl2与IGFIR间、bcl2与PCNA间无相关关系(P>0.05)。结论：(1)IGFIR蛋白、癌基因bcl2和PCNA的异常表达在贲门癌变过程中具有重要作用。(2)贲门癌组织中IGFIR、bcl2、PCNA表达在肿瘤不同分化程度和不同民族间无显著差别。

    关键词: 贲门腺癌；胰岛素样生长因子I受体(IGFIR)、细胞凋亡相关基因2(bcl2)及增殖细胞核抗原(PCNA) ；不同民族；免疫组化

    Biopathological significance of the abnormal expression of IGFIR, bcl2,PCNA in cardiac cancer tissues in Xinjiang

    MA Yuqing，QING Song, LIU Xia

    (Department of Pathology, First Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)

    Abstract: Objective: To detect the abnormal expression of IGFIR protein, bcl2 oncogene and proliferating cell nuclear antigene (PCNA) in cardiac cancer tissues in different ethnic patients, and the molecular biology of cardiac carcinogenesis. Methods: The over expression of IGFIR, bcl2and PCNA on paraffin embedded tumor tissues in 90 different ethnic patients with cardinal adenocarcinoma (Kazak 29, Uygur 30, Han 31) were examined by immunohistochemistry(LSAB). Results: The positive frequency of IGFIR, bcl2 and PCNA in cardial cancer were 84.44%(76/90), 87.78%(79/90), 97.78%(88/90) respectively. And the expression of those in noncancer tissue were 47.62%(10/21), 52.38%(11/21), 0%(0/21). There were statistic significances between cancer and noncancer (P<0.01). However, no difference of the expression of IGFIR, bcl2, PCNA among different ethnic as well as varing degrees of differentiation were found (P>0.05). No significant correlationship was found between bcl2 and PCNA, between bcl2 and IGFIR (P>0.05). Conclusion: The abnormal expression of mutant IGFIR, bcl2 and PCNA may be an important etiopathogenesis factor for cardial carcinogenesis. No statistic difference on the expression of IGFIR, bcl2 and PCNA among different ethnic was found as well as varing degrees of differentiation. ......

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