性脊髓_____NFκB；_脊髓空洞症；

实验性脊髓空洞前状态神经元凋亡及NFκB，Bcl2和Bax的调控作用

http://www.100md.com 《第四军医大学学报》 2006年第5期

性脊髓,,NFκB；,脊髓空洞症；,TUNEL法；,免疫组化；,细胞凋亡,0引言,1材料和方法,2结果,3讨论,【参考

     Effect of NFκB, Bcl2 and Bax on neuronal apoptosis in experimental presyrinx state

    SUN GuoZhu1, ZHANG QingJun2, ZHANG GengShen1, LI JianFeng1

    1Department of Neurosurgery, Second Hospital, Hebei Medical University, Shijiazhuang 050000, China, 2Department of Neurosurgery, Peoples Hospital, Peking University, Beijing 100044, China

    【Abstract】 AIM: To investigate neuronal apoptosis in experimental presyrinx state and the regulatory role and mechanism of NFκB, Bcl2 and Bax in rabbits. METHODS: The experimental syringomyelia models of rabbits were established by intracisternal injection of Kaolin. Neuronal apoptosis and the expressions of NFκB, IκB, Bcl2 and Bax were measured with TUNEL and immunohistochemistry in 1, 3, 7, 14 and 21 d after operation respectively. RESULTS: Compared with that in control group, the NFκB expression in Kaolin group increased from the 1st day after operation, reached its peak at 3rd day, remained there till 7th day, and returned to a normal level at 14th day approximately. The IκB expression showed a negative correlation with NFκB at the same time points. The Bcl2 and Bax expressions increased from the 1st day, reached its peak at 7th day, remained there till 14th day, and then began to drop. CONCLUSION: In presyrinx state of experimental syringomyelia, the increasing expression of NFκB mainly upregulates its target gene Bax, thus inducing neuronal apoptosis to involve in nervous function injury. ......

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