基因_____ApoE基因；基因多态性；高脂血症

ApoE基因多态性与血脂水平的相关性

http://www.100md.com 《第四军医大学学报》 2006年第5期

基因,,ApoE基因；基因多态性；高脂血症,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Correlation between apolipoprotein E gene polymorphism and plasma lipid level

    LIU YingLi1，LI JianKe2，YAN ZiQiang3, CHEN YanJiong4

    1Affiliated Hospital， 2Department of Food and Engineer， Shaanxi Normal University, Xian 710062, China, 3PLA 451 Hospital, 4Medical College of Xian Jiaotong University, Xian 710061, China

    【Abstract】 AIM: To evaluate the effects of apolipoprotein E (ApoE) gene polymorphism on the plasma lipid level. METHODS: Seventytwo hypertensive patients (male 46, female 26) and 95 healthy controls (male 46, female 49) were examined for their plasma lipid level (TC, TG, HDLC and LDLC) and ApoE gene type. RESULTS: The allele frequency distribution was similar between the 2 groups and ε3 allele frequency distribution was the highest, which was 80.5% in normal group and 76.8% in hyperlipemia group. ε2 and ε4 allele frequency distributions were lower than ε3. There was no significant difference between different sexes. ApoE gene type was correlated with serum lipid levels. Serum lipid be normal or not, TC and LDLC level was ε2/3﹤ε3/3﹤ε3/4 and HDLC was ε3/4﹤ε3/3﹤ε2/3. CONCLUSION: ApoE gene polymorphism is significantly correlated with serum lipid level. ......

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