羟丙基__(期刊论文)

羟丙基β环糊精毛细管电泳法测定1,2二苯基乙二醇的对映体过量值

http://www.100md.com 《第四军医大学学报》 2006年第5期

羟丙基,,电泳,毛细管；1,2二苯基乙二醇；对映体；手性分离；立体异构体,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Enantiomeric excess analysis of 1,2diphenyl1,2ethanediol by capillary electrophoresis using HPβCD as chiral selectors

    ZHAO Yan1, YANG XingBin2, JIANG Ru1，SUN XiaoLi1, LIU WenMin1, ZHANG ShengYong1

    1Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xian 710033, China, 2College of Life Science, Key Laboratory for Officinal Plant Resource and Pharmaceutical Chemistry of Ministry of Education, Shaanxi Normal University, Xian 710062, China

    【Abstract】 AIM: To develop a new method to determine enantiomeric excesses (e.e.%) of 1,2diphenyl1,2ethanediol by capillary electrophoresis (CE). METHODS: The effects of the concentration of buffer and hydropropylβcyclodextrin ( HPβCD), pH, running voltage and capillary temperature on the enantioseparation of 1,2diphenyl1,2ethanediol were investigated by CE. Enantiomeric excesses of 4 samples synthesized by asymmetric dihydroxylation were investigated and the results determined by CE method were then evaluated by comparison with those by HPLC. RESULTS: Under the optimized conditions of 200 mmol/L boric acid buffer of pH 9.8 containing 15 mmol/L HPβCD, at capillary temperature 20℃ and separation voltage 15 kV, 1,2diphenyl1,2ethanediol was completely separated with resolution as high as 3.35. Synchronously, the e.e.% of the 4 batches of samples determined by CE was consistent with that by HPLC. CONCLUSION: This method is simple, precise and can be applied to the chiral separation of 1,2diphenyl1,2ethanediol enantiomers and determination of e.e.%. ......

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