ASC在大鼠胰腺炎肺损伤发病中的作用及中药清胰汤对其表达的影响
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任双义, 陈海龙
重症急性胰腺炎;肺损伤;ASC;白细胞介素1任双义,陈海龙.ASC在大鼠胰腺炎肺损伤发病中的作用及中药清胰汤对其表达的影响. 世界华人消化杂志2006;14(11)1058-1063
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任双义, 大连医科大学附属第二医院普外科 辽宁省大连市 116023
陈海龙, 大连医科大学附属第一医院普外科 辽宁省大连市 116011
任双义, 医学硕士, 博士在读, 从事普通外科和中西医结合外科临床研究.
国家自然科学基金资助项目, No. 30271667
通讯作者: 陈海龙, 116011, 辽宁省大连市西岗区中山路222号, 大连医科大学附属第一医院普外科. rsydl@yahoo.com.cn
收稿日期: 2005-11-30 接受日期: 2005-12-24
Role of apoptosis-associated speck-like protein containing a Caspase recruitment domain in pathogenesis of lung injury induced by severe acute pancreatitis in rats and effect of Qingyitang on its expression
Shuang-Yi Ren, Hai-Long Chen
Shuang-Yi Ren, Department of General Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Hai-Long Chen, Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Supported by National Natural Science Foundation of China, No. 30271667
Correspondence to: Hai-Long Chen, Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China. rsydl@yahoo.com.cn
Received: 2005-11-30 Accepted: 2005-12-24
AbstractAIM:To study the pathogenesis of ASC (apop-tosis-associated speck-like protein containing a Caspase recruitment domain) in acute lung injury (ALI) induced by severe acute pancreatitis (SAP) and the effect of Chinese medicine Qingyitang on the expression of ASC and cytokines in rats.
METHODS: Forty Sprague Dawley (SD) rats were randomized into four groups: sham operation group (SHAM, n = 10), ALI models (ALI, n = 10), ALI + Sandostatin (SS, n = 10), ALI + Qingyitang (QYT, n = 10). ALI during SAP was induced by retrograde infusion of 15 g/L sodium deoxycholate into the bili-pancreatic duct in SD rats. All the rats were killed 24 hours after operation and treatment. Serum amylase was measured by an automated HITACHI analyzer. The level of myeloperoxidase (MPO) in pulmonary tissues was measured by enzyme chemistry assay ......
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