板蓝根_____板蓝根；_抗内毒素活性；

板蓝根高极性部位增强F022抗内毒素活性的研究

http://www.100md.com 《时珍国医国药》 2006年第2期

板蓝根,,板蓝根；,抗内毒素活性；,TNF-α；,IL-6,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的研究板蓝根高极性部位(Ftp)与板蓝根F022部位协同抗内毒素作用。方法ELISA法检测内毒素刺激鼠腹腔巨噬细胞分泌肿瘤坏死因子α(TNF-α)、白介素6(IL-6)水平，内毒素致BCG增敏小鼠死亡实验。结果Ftp联合F022处理巨噬细胞，能显著抑制TNF-α和IL-6水平，效果优于单用F022组；Ftp联用F022显著延长BCG增敏小鼠受内毒素攻击后的存活时间。结论Ftp本身抗内毒素活性较弱，但与F022部位合用，可进一步增强F022部位的抗内毒素作用。

    关键词：板蓝根；抗内毒素活性； TNF-α； IL-6

    Top-polar Fraction Developing Anti-endotoxin Activity of F022 from Radix Isatidis

    LIN Aihua1， LIU Yiming1， QIU Xiaohui1， LIU Yunhai2

    (1.The Second Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510120, China; 2.Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China)

    Abstract:ObjectiveTo study the anti-endotoxin synergistic effect of top-polar fraction (Ftp)and F022 from Radix Isatidis. MethodsThe production of TNF-α and IL-6 of murine peritoneal macrophages stimulated by LPS was measured by ELISA. The lethality of BCG-primed mice was induced by LPS.ResultsFtp and F022 was added simultaneously to macrophages culture 1h before addition of LPS, Production was remarkably inhibited. Ftpand F022 remarkably protected BCG-primed mice from LPS induced lethality.ConclusionThese results suggest that Ftp can develop the anti-endotoxin activity of F022 from Radix Isatidis. ......

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