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低剂量60Coγ射线75 mGy全身照射对小鼠血浆中IL12和IL10的影响
http://www.100md.com 《海军医学杂志》 2005年第2期
辐射免疫学,,]60Coγ射线;辐射;IL12;IL10;辐射免疫学,低剂量60Coγ射线75mGy全身照射对小鼠血浆中IL12和IL10的影响,1材料和方法,2结果,3讨论,[参
     [摘要]目的:研究低剂量辐射对免疫系统影响的剂量率效应。方法:采用高、中、低3个不同剂量率的60Coγ射线,同一照射剂量75 mGy,全身一次性照射小鼠,ELISA分析照射4 h后血浆IL12和IL10的含量变化。结果: 3个剂量率照射后小鼠血浆中IL12、 IL10和IL12/IL10均出现不同程度的下降,并随着剂量率增加呈现“下降-低点-回升”的“V”字型变化。结论: 在低剂量辐射对免疫系统的影响中,存在波动性的剂量率效应。

    [关键词]60Coγ射线;辐射;IL12;IL10;辐射免疫学

    Effect of low dose gamma irradiation at different dose rates on the level of IL12 and IL10 in the sera of mice

    ZHU Qing, GAO Jun, LONG Jianqiu, et al

    (Naval Medical Research Institute, Shanghai 200433,China)

    Abstract: Objective: To study the effect of low dose 60Coγ radiation at different dose rates on the level of IL12 and IL10 in the sera of mice. Methods: The experimental animals, Kunmin mice, 3 weeks old, were exposed to whole body irradiation with a dose of 75 mGy at three different dose rates of 0.5 mGy/min, 5 mGy/min, and 50 mGy/min respectively. Changes in the contents of IL12 and IL10 in sera were analyzed by using ELISA ......

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