比格犬经口给芩栀胶囊的长期毒性实验
比格,,芩栀胶囊；长期毒性；比格犬,1材料,2方法和结果[1，2],3讨论,参考文献：
摘要：目的观察芩栀胶囊对比格(Beagle)犬有无长期毒性作用。方法芩栀胶囊以4.0，8.0，16.0 g/kg剂量(分别相当于临床成人日用剂量的10，20，40倍)，连续给Beagle犬灌胃给药28 d，停药14 d,分别称量动物体重，计算脏器系数，测定血液学和血液生化学指标，并作心电图和病理组织学检查。结果芩栀胶囊各剂量组动物的一般状况、体重、摄食量、主要脏器系数、心电图、血液学指标及血液生化学指标，与正常对照组比较，均未见明显差异；病理检查未见与药物毒性相关的主要脏器组织形态学改变；停药后也未见药物延迟性毒性反应。结论 芩栀胶囊长期用药无明显毒性，推测临床拟用剂量是安全的。关键词：芩栀胶囊；长期毒性；比格犬
The Beagle Dog Chronic Toxicity Test of Qinzhi Capsule Taken Orally
YAO Gan, HE Zongyu, FANG Taihui
(1.College of Bioinformation of Chongqing University of Posts and Telecommunications,Chongqing 400065,China; 2.Nanjing University of TCM, Nanjing 210029,China)
Abstract：ObjectiveTo observe the Beagle dog chronic toxicity induced by Qinzhi Capsule taken orally. MethodsThe Beagle dogs were orally given Qinzhi Capsule for 28 days with the doses of 4.0,8.0 and 16.0g(crude medicinal materials)/kg(10,20 and 40 times of clinic dose) and for 14 days of stopping administration. The Beagle dog’s weights, organ coefficients, the indexes of hematology and biochemistry were determined. The cardiogram and the pathological examination were carried out. ResultsThe outer appearance and behavior, weights, organ coefficient, the cardiogram, the indexes of hematology and biochemistry in Beagle dogs had no significant difference by comparing with control group. The pathological examination did not discover significant pathological changes related to drug toxicity and the delayed toxicity reaction after drug administration. ConclusionQinzhi Capsule has no significant toxicity for long-term administration on Beagle dogs. It infers that the drawing up doses in clinic will be safe. ......
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