血管紧张素II_____血管紧张素II;

心衰患者心肌重构的信号转导机制研究

http://www.100md.com 《第四军医大学学报》 2005年第4期

血管紧张素II,,血管紧张素II;,心肌病,肥厚性;,钙神经素;有丝分裂素激活蛋白激酶类,1对象和方法,2结果,3讨论,【参考文献】

     Signal regulation mechanism of myocardium remodeling in patients with congestive heart failure

    ZHOU XingWen, ZHANG Xin, YANG YongJian

    Department of Cardiovasology, General Hospital of Chengdu Military Command,Chengdu 610083, China

    【Abstract】 AIM: To investigate the signal regulation of extra cellular signal regulation kinase (ERK1/2) and calcineurin(CaN)in fetal heart gene of cardiomyocytes in myocardium of patients with congestive heart failure (CHF).METHODS: Thirtynine patients of mitral valve disease with CHF were randomly selected and 30 cases of healthy persons were included as controls.Immunoprecipitation was used to assay the protein expression and phosphorylation of CaN and ERK1/2,and the protein expression of αskeletalactin in myocardial tissues.The mRNA expression of βmyosin heavy chain(β MHC)was measured by RTPCR.RESULTS: The myocardium in patients with CHF showed typical pathological changes of myocardium remodeling.The phosphorylation of CaN,protein expression of ERK1/2,CaN and αactin,and βMHC mRNA expression also increased in myocardial tissues in CHF groups,and were positively correlated to the cardiac function.CONCLUSION: Both CaN and ERK1/2 pathways activate fetal heart gene expression of cardiomyocytes,which may play some important roles in the pathogenesis of myocyte hypertrophy. ......

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