摘要 :目的 探讨急性脑出血大鼠脑内热休克蛋白HSP 70 与凋亡蛋白Bcl-2的表达变化。 方法 成年雄性SD大鼠随机分为生理盐水对照组与脑出血组(36只)，采用自体血注入方法建立大鼠脑出血模型。免疫组织化学法检测HSP 70 与Bcl-2的表达。 结果 免疫组化示HSP 70 与Bcl-2在脑内广泛表达，模型组HSP 70 出血后6h出现阳性细胞表达，24h有较明显的表达，72h阳性细胞表达仍在增加;Bcl-2阳性细胞12h表达开始增加，48h达高峰。 结论 急性脑出血后大鼠脑内HSP 70 与Bcl-2表达均增强，二者均以皮质和海马区表达为主。

    关键词 :脑出血;免疫组织化学;大鼠

    Expression of HSP70 and Bcl-2in rat brain after experimental intracerebral hemorrhage

    WEI Xiu-e，SHI Hong-juan，RONG Liang-qun，et al

    (Department of Neurology，Second Affiliated Hospital of Xuzhou Medical College，Xuzhou，Jiangsu221002，China)

    Abstract:Objective To investigate the expression of HSP 70 and Bcl-2in rat brain after acute intracerebral hemorrhage(ICH).Methods Rats were randomly divided into a NS control group and a model group(n=36each).ICH model was es-tablished by injecting50μl of autologous blood into the caudate nucleus.At six time points(6h ......