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中药肺痨宁对复治肺结核病人的免疫调节作用
http://www.100md.com 《齐鲁医学杂志》 2006年第1期
肺痨宁,,],肺痨宁;结核,肺;免疫活性,1资料和方法,2结果,3讨论,[参考文献]
     [摘要] 目的 探讨中药肺痨宁对复治肺结核的免疫调节作用。方法 将67例复治菌阳浸润型肺结核病人随机分为治疗组(n=34)和临床对照组(n=33)。治疗组在常规抗结核治疗的同时加用肺痨宁,临床对照组只采用常规抗结核治疗,方案同治疗组。用酶联免疫吸附法(ELISA)检测两组治疗前及治疗1、3个月时病人血清中白细胞介素12(IL12)和γ干扰素(IFNγ)水平,同时以30例健康查体者作为正常对照组。结果 治疗前,治疗组与临床对照组的IFNγ、IL12值均低于正常对照组,差异有显著意义(F=13.962、5.275,q=2.898~6.975,P<0.05、0.01)。治疗组治疗1、3个月后IFNγ、IL12水平均较治疗前升高,差异有显著性(t=2.403~9.575,P<0.05、0.01)。临床对照组治疗3个月后IFNγ、IL12较治疗前升高,差异有显著性(t=3.396、2.951,P<0.01)。与临床对照组比较,治疗组治疗1个月后IL12水平升高,治疗3个月后IFNγ水平升高,差异均有显著性(t=2.433、4.463,P<0.01)。结论 中药肺痨宁可显著提高复治肺结核病人的细胞免疫功能。

    [关键词] 肺痨宁;结核,肺;免疫活性

    IMMUNOTHERAPEUTIC EFFECT OF FEILAONING ON RETREATED PULMONARY TUBERCULOSIS

    LI TONGXIA, QIU MEIJIAN, JI HAILING

    (Qingdao Chest Hospital, Qingdao 266043, China)

    [ABSTRACT]ObjectiveTo assess the effects of Feilaoning on retreated pulmonary tuberculosis. MethodsSixtyseven patients with retreated pulmonary tuberculosis were randomly divided into a trial group [34 cases, treated with 3Pa(H)L2VZ(TH)E(Ak)+Feilaoning /6Pa(H)L2V] and a control group [33 cases, treated with 3Pa(H)L2VZ(TH)E(Ak)/6Pa(H)L2V]. The levels of IL12 and IFNγ were detected with ELISA.ResultsThe level of IL12 was (37.27±15.52)ng/L in the trial group after one month of therapy. There was significant difference between the two groups (F=13.962,5.275;q=2.898-6.975;P<0.05,0.01). The level of IFNγ was (11.209±3.281)ng/L in the trial group after three months of treatment. A significant difference was noted between the two groups (t=3.396,2.951;P<0.01).ConclusionFeilaoning can improve the cellular immunity of the patients with retreated pulmonary tuberculosis. ......

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