[摘要]目的 研究胎儿生长受限(FGR)与瘦素、胰岛素样生长因子.Ⅰ(IGF.Ⅰ)的关系，探讨脐血瘦素、IGF.Ⅰ的临床检测价值。 方法 采用放射免疫法检测40例正常孕妇(对照组)和24例FGR孕妇(FGR组)的血清与脐血(脐A和脐V)中瘦素和IGF.Ⅰ水平，并对其结果进行相关性分析。 结果 (1)FGR组血清瘦素及IGF.Ⅰ水平与对照组比较，差异无显著性(P>0.05);(2)FGR组脐血瘦素和IGF.Ⅰ水平均明显低于对照组(P<0.01，P<0.05)。(3)两组孕妇血清瘦素和IGF.Ⅰ水平与脐血瘦素和IGF.Ⅰ水平无相关性(r=0.129，r=-0.059，均P>0.05);脐血瘦素水平与新生儿出生体重呈正相关关系(r=0.600，P<0.05)，与胎盘重量亦呈正相关关系(r=0.44，P<0.05);脐血IGF.Ⅰ水平与新生儿出生体重呈正相关关系(r=0.469，P<0.05)，与胎盘重量无相关关系(r=0.30，P>0.05)。(4)脐A瘦素和IGF.Ⅰ水平与相应脐V瘦素和IGF.Ⅰ水平差异无显著性(P>0.05)。(5)脐血瘦素与IGF.Ⅰ水平无相关关系(r=0.397，P>0.05)。 结论 脐血瘦素和IGF.Ⅰ水平与胎儿生长发育状态密切相关;脐血瘦素或IGF.Ⅰ水平降低可能是FGR发生的原因之一;瘦素调控胎儿生长发育没有IGF.Ⅰ的直接参与;脐A与脐V血瘦素及IGF.Ⅰ水平均可作为评价胎儿生长发育的临床指标。

    [关键词] 瘦素;胰岛素样生长因子.Ⅰ;胎儿生长受限;脐动脉;脐静脉

    The relationship between fetal growth reatriction and levels of leptin，IGF.Ⅰ

    JIANG Xiao-qing，WANG Jing，YU Hong

    (Department of Obstetrics and Gynecology，Zhongda Hospital，Southeast University，Nanjing210009，China)

    Abstract:Objective To study the relationship between fetal growth reatriction(FGR)and levels of leptin，insulin-like growth factor I(IGF.Ⅰ).Methods The levels of leptin and IGF.Ⅰin serum and cord blood in24FGR pregnant women(FGR group)and40normal pregnant women(control group)were measured by radioimmuno-assay(RIA)and the results in both groups were analyzed.Results 1.The difference of the levels of leptin and IGF.Ⅰin serum between FGR group and control group revealed no statistical significance(P>0.05).2.The levels of leptin and IGF.Ⅰin cord blood in FGR group were notably lower than those of controls(P<0.01;P<0.05).3.The serum levels of leptin and IGF.Ⅰwere not correlative to the cord blood levels of both constituents in two groups(r=0.129 ......