【摘要】 目的 探讨盐酸舍曲林对高血压伴焦虑患者血压和生活质量的影响。方法 对100例高血压患者进行焦虑自评量表(SAS)评分，将评分阳性者随机分为治疗组(苯磺酸氨氯地平片+盐酸舍曲林片)及对照组(苯磺酸氨氯地平片)，评分阴性者为无焦虑组(苯磺酸氨氯地平片)。观察治疗6周后三组患者降压效果及生活质量评分。结果 治疗组、无焦虑组较对照组降压效果明显提高，治疗组SAS评分显著低于对照组，生活质量评分显著高于对照组。结论 盐酸舍曲林治疗高血压伴焦虑患者能明显提高降压疗效，显著降低高血压患者焦虑的严重程度，提高生活质量。

    【关键词】 高血压；焦虑；生活质量；盐酸舍曲林

    The clinical effects of Zoloft on anxiety of patients with essential hypertension

    LU Qian, ZHANG Shu-fu, CHEN Nan-nan，et al.

    Yangpu District Center Hospital, Shanghai 200090， China

    【Abstract】 Objective To investigate the effects of Zoloft on essential hypertensive subjects with anxiety and to explore its clinical implications.Methods After evaluating 100 cases with essential hypertension by SAS, the subjects with positive results who were followed for 6 weeks from baseline assessments were randomly divided into experimental group (Norvasc and Zoloft ) and control group (only Norvasc) and the subjects with negative results were regarded as non - anxiety group. The effects of reduce blood pressure, the scores of SAS and quality of life were compared between 3 guoups.Results In experimental groups and non - anxiety groups , the effects of reduce blood pressure significantly better than those of control group.The scores of SAS in experimental groups were significantly lower and the scores of quality of life were significantly higher than those of control groups.Conclusion Zoloft on essential hypertensive subjects with anxiety could significantly improve clinical outcome, and also lower the degree of psychological obstacle , improve quality of life of essential hypertension patients. ......