对甲氧基肉桂酸__(期刊论文)

对甲氧基肉桂酸乙酯的合成研究

http://www.100md.com 《广东药学院学报》 2005年第2期

对甲氧基肉桂酸,,对甲氧基肉桂酸；对甲氧基肉桂酸乙酯；Knoevenagel缩合；微波辐射；酯化,2结果与讨论,3结论,参考文献

     摘要目的与方法以对甲氧基苯甲醛为原料，醋酸铵为催化剂，经Knoevenagel反应，采用微波辐射技术合成了中间体对甲氧基肉桂酸，再以对甲苯磺酸为催化剂，经酯化反应得对甲氧基肉桂酸乙酯。结果与结论两步反应的产率分别为87.8%和91.0%，产品结构经IR和1HNMR(CDCl3)确证。

    关键词对甲氧基肉桂酸；对甲氧基肉桂酸乙酯；Knoevenagel缩合；微波辐射；酯化

    Synthesis of ethyl pmethoxy cinnamate

    ZHANG Hong，DING Yinghong，LI Ruoqi

    (Department of Organic Chemistry，Guangdong College of Pharmacy， Guangzhou 510240，China)

    Abstract An efficient synthesis of pmethoxy cinnamic acid, a key intermediate for ethyl pmethoxy cinnamate, was developed on the basis of Knoevenagel condensation of panisaldehyde with a catalytic amount of ammonium acetate under microwave irradiation in the yield of 87.8%. Then, pmethoxy cinnamic acid obtained was converted to ethyl pmethoxy cinnamate by esterification using ptoluenesulfonic acid as catalyst in excellent yield (91.0%). The structures of pmethoxy cinnamic acid and ethyl pmethoxy cinnamate were confirmed by IR and 1HNMR.

    Key words pmethoxy cinnamic acid；ethyl pmethoxy cinnamate；Knoevenagel condensation；microwave irradiation；esterification

    280～320 nm区域的紫外线易使皮肤晒伤 ......

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