奥拉西坦_____奥拉西坦；注射液；

HPLC法测定奥拉西坦注射液中奥拉西坦的含量

http://www.100md.com 《广东药学院学报》 2006年第1期

奥拉西坦,,奥拉西坦；注射液；,含量测定；,高效液相色谱法,1仪器与试药,2方法与结果,3讨论,参考文献:

     摘要:目的建立奥拉西坦注射液中奥拉西坦的含量测定方法。方法高效液相色谱法，用氨基硅烷键合硅胶为填充剂，流动相为乙腈水(体积比80∶20)，检测波长210 nm。结果奥拉西坦质量浓度在0.025~0.20 mg/mL范围内与峰面积呈良好的线性关系(r=10000)；精密度、重复性试验结果RSD分别为0.10 %和0.30 %；平均回收率为100.85 %，RSD＝0.79 %。结论本法简便，灵敏，准确，重现性好，建立的定量方法可用于控制该注射液的质量。

    关键词:奥拉西坦；注射液；含量测定；高效液相色谱法

    Determination of oxiracetam in oxiracetam injection by HPLCLIN Dongxuan,CHEN Yongxin

    (Guangdong Institute for Drug Control,Guangzhou 510180,China)

    Abstract: Objective To establish a quick and efficient highperformance liquid chromatographic assay for the determination of oxiracetam in oxiracetam injection. Method Chromatography was performed on a column (250/4.6 NUCLEOSIL 1005 NH2) using acetonitrilewater (80∶20) as the mobile phase under the detection wavelength of 210 nm. Result The linear range was 0.025~0.20 mg /ml(r=1.0000). The average recovery was 100.85 % and RSD 0.79 %. Conclusion The method is convenient,sensitive and accurate for the quality control of oxiracetam injection.

    Key words:oxiracetam; oxiracetam injection; content determination; HPLC

    奥拉西坦注射液主要成分为奥拉西坦 ......

百拇医药网 http://www.100md.com/html/DirDu/2006/05/31/98/05/95.htm

您现在查看是摘要页，全文长 4982 字符。