腺苷_____腺苷；菌种；_选育(期刊论文)

腺苷产生菌Xn151菌种选育研究

http://www.100md.com 《广东药学院学报》 2005年第2期

腺苷,,腺苷；菌种；,选育,1材料与方法,2结果与分析,3讨论,参考文献

     摘要以肌苷产生菌枯草杆菌GMI741为出发菌株，通过多因子诱变选育出具有黄嘌呤、鸟嘌呤双重营养缺陷型、丧失腺嘌呤脱氨酶的腺苷产生菌Xn151，摇瓶发酵96 h产腺苷达16.3 g·L-1。

    关键词腺苷；菌种；选育

    A study of the breeding of an adenosineproducing strain Xn151

    SHI Qingshan, LIN Xiaoping,XU Hong, LI Liangqiu, QIU Yutang

    (Guangdong Institute of Microbiology/Guangdong Provincial Key Laboratory of Microbial Preservation and Application，Guangzhou 510070,China)

    Abstract The induction of adenosineproducing strain from an inosineproducing strain Bacillus substilis GMI741 was attempted, and it was found out that a double auxotrophic mutant (xanthine and guaninerequiring) Bacillus substilis Xn151 lacking of adenase produced a large amount of adenosine. On a reciprocal shaker for 96 h, the accumulation of adenosine by Xn151 in the broth culture was more than 16.3 g·L-1.

    Key words Bacillus substilis；adenosine；strain breeding

    腺苷(Adenosine)，学名腺嘌呤核苷(9βDRibofuranosyl adenine)；是一种天然存在的遍布人体细胞的内源性嘌呤核苷，是三磷酸腺苷(ATP)的降解产物。腺苷以其扩张血管作用而被人们所熟知，具有广泛的心脏效应以及快速显著的冠脉扩张作用。大量的研究表明，腺苷还具有触发或介导缺血预适应、减轻再灌注损伤等心脏保护效应；另外利用腺苷还可制成许多药物如嘌呤霉素、高瓜氨基腺苷、赖氨酰氨基腺苷、琥珀酰5＇腺苷酸、s腺苷蛋氨酸等核酸类药物[1] ......

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