丹参饮对实验性胃溃疡的防治作用
丹参饮,,],丹参饮；胃溃疡；动物，实验,1材料与方法,2结果,3讨论,[参考文献]
[摘要] 目的：观察丹参饮对实验性胃溃疡的影响。方法：采用小鼠水浸束缚应激性胃溃疡模型、大鼠乙酸烧灼性胃溃疡模型和大鼠幽门结扎性胃溃疡模型进行实验，并检测大鼠胃液酸度、胃蛋白酶活性和胃壁结合黏液的含量。结果：丹参饮能够减轻小鼠水浸束缚应激性胃黏膜损伤，5.0、10.0 g/kg剂量组作用明显优于生理盐水对照组(P<0.05或P<0.01)；显著促进大鼠乙酸烧灼性溃疡愈合(P<0.01)，增加其胃壁结合黏液的含量(P<0.01)；还能够抑制幽门结扎所致胃溃疡的形成，但对胃酸分泌、胃蛋白酶活性无明显影响。结论：丹参饮具有较好的抗溃疡作用，其机制可能与增强胃黏膜防御能力有关。[关键词] 丹参饮；胃溃疡；动物，实验
Effects of Danshen Decoction on experimental gastric ulcer in rats and mice
LIU Li, ZHANG HongQuan
(Medical and Pharmaceutical Institute, Yangzhou University, Yangzhou, Jiangsu Province 225001, China)
ABSTRACT Objective: To investigate the preventive and therapeutic effects of Danshen Decoction on gastric ulcer in experimental animal models. Methods: The model of water immersion restraint stress ulcer in mice, and the models of acetic acid impaired gastric ulcer and pyloric ligation gastric ulcer in rats were established. The total gastric acid, the activity of pepsin and the amount of gastric wall binding mucus were detected. Results: Danshen Decoction reduced the acute gastric mucosal lesion. The effect of 5.0 or 10.0 g/kg group was obviously better than that of the normal saline control group (P<0.05 and P<0.01 respectively). Danshen Decoction accelerated the healing of ulcer induced by acetic acid significantly, and increased the content of gastric wall binding mucus (P<0.01); and it also inhibited the formation of gastric ulcer induced by pyloric ligation, while having no influence on the secretion of gastric acid and the activity of pepsin. Conclusion: Danshen Decoction has a significant antiulcerative effect, which may be related to improving the gastric mucosal defensive function. ......
您现在查看是摘要页，全文长 11562 字符。