核因子_____核因子；胰腺炎；小鼠(期刊论文)

L精氨酸诱导的小鼠急性胰腺炎中NFκB活性的阻断及其对炎症发展的抑制效应

http://www.100md.com 《广东药学院学报》 2004年第5期

核因子,,核因子；胰腺炎；小鼠

     Inhibition of NFκB′s activity attenuates Larginine mice pancreatitis inflammatory development

    CHEN Ken, ZHENG JIShun, LONG YOUMing

    (1.Department of Clinical Medicine, Guangdong College of Pharmacy, Guangzhou 510240, Guangdong Province, China;

    2. Department of Digestion, No. 1 Hospital of Hefei City, Hefei 230061, Anhui Province, China)

    Abstract Objective To demonstrate the effects and significance of blocked NFκB activity with pretreatment of pyrrolidine dithiocarbamate (PDTC) or Nacetylcysteine (NAC). Methods Mouse acute pancreatitis was induced by injecting 20% Larginine saline solution (2×2.0 mg/g body weight) intraperitoneally at 1 h interval. 1 h prior to Larginine administrated intraperitoneally, 0.01 mg/g pyrrolidine dithiocarbamate (PDTC) or 0.1 mg/g Nacetylcysteine (NAC) was injected as pretreatment. Mice were respectively killed at various time following the second time Larginine administration. NFκB activity, IL6 level, amylase activity in serum, wet/ dry quality ratio of the pancreas, and their histological structures were measured and observed. Results NFκB obviously activated in pancreatitis induced by Larginine. PDTC or NAC pretreatment markedly blocked NFκB activation in pancreas and attenuated pancreatitis development. But there were no significant changes in serum amylase levels. Conclusions The results suggest that NFκB activation is an important early event and the pretreatment of PDTC and NAC improves pancreatitis by blocking activity of NFκB. ......

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