克拉霉素片_____克拉霉素片；含量；比色法；半成品

比色法测定克拉霉素片半成品含量

http://www.100md.com 《广东药学院学报》 2003年第3期

克拉霉素片,,克拉霉素片；含量；比色法；半成品,1仪器与试剂,2实验部分,3讨论

     摘要采用比色法测定克拉霉素片半成品含量。检测波长482 nm,吸收度与浓度(12~36 μg/mL)之间呈良好的线性关系(r=0.9999),批内精密度RSD=0.1%(n=5),含量为80%、100%、120%的模拟回收率分别是99.8%、995%、996%，RSD<0.5%，此法简单，快速，结果准确可靠。

    关键词克拉霉素片；含量；比色法；半成品

    Colourimetry determination of clarithromycin tablets

    FENG Yuhuan

    (Ranbaxy Limited Guangzhou,Guangzhou,Guangdong 510380)

    Abstract Colourimetry method was established for the determination of clartithromycin tablets bulk substance,detected at 482 nm,The standard curve was linear in the range of 12~36μg/mL and the correlation coefficient was 0.9999,The recovery were 99.8%,995%,99.6% when the drug content were 80%,100%,120% respectively,with RSD<0.5%. This method is simple,rapid and accurate.

    Key words clarithromycin; tablets; assay; colourimetry; bulk

    克拉霉素为红霉素结构中6位上羟基被甲氧基取代而得 ......

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