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HPLC法测定注射用加替沙星中加替沙星的含量
http://www.100md.com 《广东药学院学报》 2004年第6期
加替沙星,,加替沙星;注射用加替沙星;反相高效液相色谱法,1仪器与试药,2方法与结果,3讨论,参考文献
     摘 要 目的 测定注射用加替沙星中加替沙星的含量。方法 采用反相高效液相色谱法,色谱柱为C18,ψ(乙腈∶甲醇∶醋酸-三乙胺缓冲液∶十二烷基磺酸钠)=30∶40∶30∶0.25 g为流动相。流速为1.0 mL/min,检测波长为290 nm。结果 加替沙星在8.05~161.0 μg/mL范围内线性关系良好(r=0.9996),平均回收率为99.9%,RSD为0.4%。结论 本法准确、灵敏、可靠,能有效地控制该制剂的质量。

    关键词 加替沙星;注射用加替沙星;反相高效液相色谱法

    HPLC determination of gatifloxacin in gatifloxacin for injection

    WANG Changding,FU Xiujuan ,LIN Lizhen

    (Hainan Sanye Pharmaceutical Co., Ltd., Haikou 570226, China)

    Abstract Objective Assay gatifloxacin in gatifloxacin for injection. Methods RPHPLC method was applied in assay with C18 column, with the mobile phase of ψ(acetonitrile: methanol: acetic acidtriethylamine buffer: sodium dodecyl sulfate)=30∶40∶30∶0.25 and detection wavelength of 290 nm. Result Gatifloxacin showed linear correlation in the range of 8.05~161.0 mg/mL (r=0.9996) with recovery of 99.9% and RSD of 0.4%. Conclusion The method is accurate and reliable, and can be used in quality control of gatifloxacin for injection.

    Key words gatifloxacin; gatifloxacin for injection; RPHPLC

    注射用加替沙星(gatifloxacin)为氟喹诺酮类抗菌药 ......

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