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甘草酸脂质体的处方及制备工艺
http://www.100md.com 《第四军医大学学报》 2006年第7期
甘草酸,,甘草酸;脂质体;均匀设计法;包封率,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Formulation and preparation of glycyrrhizic acid liposome

    CHENG JianFeng, HU BenQuan, LIU Mei, HE JianRong,YANG Sheng, WANG BiShi

    Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xian 710038,China

    【Abstract】 AIM: To optimize the prescription and preparation of encapsulated liposome. METHODS: The liposomes were prepared by conventional rotaryevaporated filmultrasonication method. The prescription and preparation of liposome were optimized by uniform design. Its shape and size distribution were detected under transmission electron microscope. A method to determine the encapsulated rate of the liposome by high performance liquid (HPLC) was established. RESULTS: Glycyrrhizic acid liposome was regular under its microphotograph and the diameter was 40-60 nm. The entrapment efficiency of the glycyrrhizic acid liposome was 63.0%-89.0%. CONCLUSION: The entrapment efficiency of glycyrrhizic acid liposome and the stability of glycyrrhizic acid liposome prepared by conventional rotaryevaporated filmultrasonication method is good. ......

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