Effect of Oleum Cinnamomi on mice viral myocarditis caused by CVB3m

    DING Yuanª²Yuan1, XIE Yanª²Hua1, MIAO Shan1, LIAO Bo2, WANG Siª²Wang1

    1Institute of Materia Medica, School of Pharmacology, Fourth Military Medical University, Xi¬ðan 710033, China, 2Department of Orthopaedic, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China

    ¡¾Abstract¡¿ AIM: To investigate the therapeutic effect of Oleum Cinnamomi(OC), volatile oil of cassia bark, on mice viral myocarditis caused by coxsackie virus B3m(CVB3m). METHODS: Male BALB/c mice were randomly divided into 6 groups: 1 control group (n=16)treated with normal saline i.p, 1 model group (n=30) treated with normal saline, 1 RA group (n=30) treated with 50 mg/kg Radix astragali injection i.p. as positive control and 3 treatment groups (30 in each group) respectively given 49.1, 36.7 and 26.5 mg/kg OC after 72 h viral inoculation. Except for the control group, the other 5 groups were all inoculated with CVB3m i.p. and were bred in insulation lab. After one week treatment, the death rate, the heart histopathologic changes, the content of CK, CKª²MB and LDH in mice serum, and MAD and SOD in myocardium were observed. RESULTS: The death rate, the histopathologic score, the content of CK and CKª²MB in mice serum and MAD in myocardium were lower and the activities of SOD were higher in 49.1 and 36.7 mg/kg OC groups than in model group (P<0.05). The death rate was lower (P<0.05) and the histopathologic changes (necrosis, degeneration and cellular infiltration) were milder in OC groups than in model group at 21 d after viral inoculation. CONCLUSION: OC has a significant therapeutic effect on treatment of viral myocarditis caused by CVB3m. ......