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体外研究白细胞介素-8在小鼠胚泡粘附和铺展中的作用
http://www.100md.com 《包头医学院学报》 2006年第2期
白细胞介素-8,,白细胞介素-8;胚泡;粘附;铺展;体外培养,摘要,关键词,1材料和方法,2结果,3讨论,参考文献
     摘 要

    目的:研究白细胞介素-8(Interleukin-8,IL-8)对小鼠胚泡粘附和铺展的影响。方法:体外无血清培养小鼠胚泡时,在FN包被的培养板中加入不同浓度的抗IL-8抗体,观察并统计胚泡的粘附率和铺展率。结果:各抗体组胚泡的粘附率和铺展率随抗体浓度的增加而下降。结论:IL-8参与小鼠胚泡的粘附和铺展过程。

     关键词 白细胞介素-8;胚泡;粘附;铺展;体外培养

    中图分类号 R3221+1

    The Stady of Effect of Interleukin -8 on Mouse Blastocyst Attachment and Outgrowth

    SONG Fang,HAO Fen,ZHAO Lijun*,BAI Huiru;CHEN Jing

    (Department of Histology and Embryology,Baotou Medical College, Baotou 014010;Department of Histology and Embryology,School of Basic Medical Science, Beijing University*)

    Abstract Objective: To study the effect of Interleukin -8(IL-8) on mouse blastocyst attachment and outgrowth.Metheds: The blastocysts were cultured in the FN-coated plates, then we observed the influences on the attachment and outgrowth of mouse blastocysts by adding anti-IL-8 antibody of different concentrations .Results: The ratio of attachment and outgrowth are inhibited significantly in a concentration-dependent manner by anti-IL-8 antibody. Conclusions:These results indicated that IL-8 maybe participate in the process of mouse blastocyst attachment and outgrowth ......

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