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差别PCR技术检测乳腺癌c–erbB-2癌基因扩增的研究
http://www.100md.com 《包头医学院学报》 2006年第2期
乳腺癌,,乳腺癌;c-erbB-2;差别PCR;癌基因扩增,摘要,关键词,1对象与方法,2结果,3讨论,参考文献
     摘要

    目的:探讨乳腺癌c-erbB-2癌基因扩增的临床意义。方法:应用差别PCR技术检测50例原发性乳腺癌c-erbB-2癌基因的扩增情况。结果:乳腺癌组织中c-erbB-2癌基因的扩增率为440%(22/50),33例有腋淋巴结转移者乳腺癌组织c-erbB-2阳性表达率(54.5%)高于17例无腋淋巴结转移者(23.5%),乳腺癌组织中c-erbB-2癌基因扩增与患者年龄、肿块大小、分化程度、病理类型、ER及PR无显著相关性。结论: c-erbB-2癌基因扩增对乳腺癌的治疗、预后判断具有重要的临床应用意义。

     关键词 乳腺癌;c-erbB-2;差别PCR;癌基因扩增

    中图分类号 R737.9

    The Study on the Detection of c–erbB-2 Oncogene in Breast Cancer Amplification with Differential Polymerase Chain Reaction

    SU Liya, CAO Hongran, BAI Xuefeng,QIN Wenbin,YUE Xiulan

    (Laboratory of Hemoglobin Baotou Medical College,Baotou 014010,China)

    Abstract Objective:To explore the clinical significance of c-erbB-2 oncogene amplification in breast cancer. Methods:c-erbB-2 oncogene amplification was examined by using differential polymerase chain reation in 50 cases of breast cancer. Results c-erbB-2 oncogene ampification was found in 440%(22/50)of breast cancer patients,the positive expression rate of c-erbB-2 was 54.5% in 33 cases of breast cancer with axillary lymph node metastasis and 23.5% in 17 cases of breast cancer without metastasis(P<0.05) ......

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